3-Bromo-1-propanol (CAS NO.: 627-18-9)

CAS NO.: 627-18-9

Content:97.00%

Application: Used in the synthesis of quaternary chiral prolines through cyclization of quaternary amino acids, fluorescent halide-sensitive quinolinium dyes, molten salt-polymers, and insect pheromones; serves as an electrophile in nucleophilic substitution reactions and redox polymerization.

Product Overview

 3-Bromo-1-propanol (also known as Trimethylene bromohydrin or 3-Hydroxypropyl bromide) CAS No.: 627-18-9 , with the chemical formula C₃H₇BrO and a molecular weight of 138.99 g/mol. It is a clear colorless to slightly yellow liquid. This compound belongs to the class of halo alcohols and is primarily used in organic synthesis and as a reagent, though it is subject to safety regulations due to its irritant properties.

Properties

3-Bromo-1-propanol exhibits the following key physical and chemical properties:

• Physical State: Liquid (at room temperature).
• Appearance: Clear colorless to slightly yellow liquid.
• Odor: Not specified.
• Melting Point: Not widely reported (approximately -57 °C based on similar compounds).
• Boiling Point: 62 °C/5 mmHg (lit.); approximately 150-160 °C at normal pressure (decomposes partially).
• Density: 1.537 g/mL at 25 °C (lit.); specific gravity 1.60.
• Solubility: 167 g/L in water at 20 °C; miscible with organic solvents like ethanol and ether.
• Stability: Stable under normal conditions; incompatible with strong oxidizing agents; may be sensitive to prolonged exposure to light.
• Toxicity: Moderately toxic; harmful if swallowed; causes skin irritation, serious eye irritation, and respiratory irritation; when heated to decomposition, emits toxic fumes of Br⁻.

Applications

The primary applications of 3-bromo-1-propanol include:

• Organic Synthesis Intermediate: Used in the synthesis of quaternary chiral prolines through cyclization of quaternary amino acids, fluorescent halide-sensitive quinolinium dyes, molten salt-polymers, and insect pheromones; serves as an electrophile in nucleophilic substitution reactions and redox polymerization.
• Reagent: Employed in the study of micellar media and microemulsions based on cationic or nonionic surfactants by reacting with phenols; acts as a grafting agent in the synthesis of recyclable reagents; used in structure-mutagenic activity relationships in bacterial strains.
• Other: Involved in the synthesis of pharmaceuticals, agrochemicals, biocides, and surfactants; enhances reactivity and stability in innovative formulations.

Classification

The following table outlines the classification of 3-bromo-1-propanol based on chemical properties, uses, and regulations: